Replens provides safe, immediate, and long-lasting relief from vaginal itching, burning, and soreness that is associated with vaginal dryness. Vaginal dryness is a common condition resulting from tampon use, childbirth, nursing, medications, stress or menopause. More comfortable applicator! How is Replens Long-Lasting Vaginal Moisturizer different? Replens' patented formula provides soothing moisture that lasts up to three days with every application. With comfortable applicators, Replens provides relief at the source of discomfort. Other products are lubricants that enhance intimacy, but do not provide long-lasting relief. Whether you experience dryness occasionally or on a regular basis, Replens is the solution for you. Estrogen-free. 8 pre-filled applicators, up to a 24-day supply.